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. 2014 Aug 26;307(9):E773–E783. doi: 10.1152/ajpendo.00148.2014

Fig. 3.

Fig. 3.

SRC1 ASO treatment increases peripheral insulin sensitivity and glucose disposal in gastrocnemius skeletal muscle in high-fat-fed rats. Sprague-Dawley rats were fed a high-fat diet and treated with control or SRC1 ASO for 4 wk. A: serum glucose levels during the hyperinsulinemic euglycemic clamp studies in rats treated with control or SRC1 ASO for 4 wk. B: glucose infusion rate in the clamp studies. C: average glucose infusion rate required to maintain euglycemia during steady state. D: insulin-stimulated peripheral glucose disposal during the hyperinsulinemic euglycemic clamp studies. E: endogenous glucose production during the hyperinsulinemic euglycemic clamp studies. F–H: glucose transport rate during the hyperinsulinemic euglycemic clamp studies into soleus muscle (F), gastrocnemius muscle (G), and WAT (H); n = 15–18/group. P value calculated by Student's t-test. *P < 0.05.