Fig. 7.

SRC1 ASO treatment increases tether-containing UBX domain for GLUT4 (TUG) cleavage in the gastrocnemius muscle. A: Western blot analysis of hexokinase II (HKII), GLUT4, GLUT1, and GAPDH in the gastrocnemius muscle of hyperinsulinemic euglycemic-clamped rats treated with insulin for 20 min. B: Western blot analysis of sortilin, TUG, TUG cleavage products, and GAPDH in the same rats described in A. C: densitometry of the Western blot analysis shown in A and B; n = 5/group. P value determined by Student's t-test. *P < 0.05.