Table 1.

Effect of SRC1 ASO on various metabolic parameters in regular chow-fed rats

	Control ASO	SRC1 ASO	P Value
Epidydimal adipose tissue weight, g	2.35 ± 0.22	2.15 ± 0.31	0.62
Plasma triglyceride, mg/dl	16.5 ± 2.14	16.2 ± 1.47	0.93
Plasma NEFA, mmol/l	0.76 ± 0.05	0.68 ± 0.04	0.21
Plasma AST, U/l	95.6 ± 15.04	72.7 ± 6.48	0.15
Plasma ALT, U/l	40.6 ± 4.62	31.3 ± 4.08	0.17
Basal glucagon, pg/ml	18.4 ± 5.7	23.5 ± 4.3	0.50
Liver triglyceride, mg/g tissue	6.98 ± 1.29	6.9 ± 1.06	0.96
Gastrocnemius muscle triglyceride, mg/g tissue	3.78 ± 0.99	1.85 ± 0.57	0.13

Values are means ± SE; n = 5–6/group. SRC1, steroid receptor coactivator 1; ASO, antisense oligonucleotide; NEFA, nonesterified fatty acid; AST, aspartate aminotransferase; ALT, alanine aminotransferase. Glucagon was measured in overnight-fasted rats treated with control or SRC1 ASO for 4 wk. All other parameters were determined in hyperinsulinemic euglycemic-clamped rats. P value calculated by Student's t-test.