Table 3.
SRC1 ASO treatment increases the expression of the insulin-sensitizing factor PGDS
| Control ASO | SRC1 ASO | P Value | |
|---|---|---|---|
| L-PGDS | 2.2 ± 1.03 | 17.28 ± 7.4 | 0.04 |
| H-PGDS | 1.07 ± 0.16 | 1.58 ± 0.42 | 0.24 |
| Leptin | 1.17 ± 0.24 | 0.69 ± 0.19 | 0.14 |
| RBP4 | 1.04 ± 0.11 | 0.82 ± 0.11 | 0.19 |
| Resistin | 1.04 ± 0.11 | 1.23 ± 0.18 | 0.38 |
| PPARγ | 1.1 ± 0.19 | 0.65 ± 0.15 | 0.10 |
| CIDEA | 1.05 ± 0.13 | 0.97 ± 0.11 | 0.65 |
| ACOX1 | 1.09 ± 0.18 | 0.80 ± 0.07 | 0.17 |
| PNPLA3 | 1.09 ± 0.18 | 0.33 ± 0.05 | 0.002 |
| PEPCK | 1.06 ± 0.14 | 0.39 ± 0.07 | 0.001 |
| LPL | 1.11 ± 0.2 | 0.92 ± 0.08 | 0.41 |
Values are mean fold change ± SE; n = 6–8/group. L-PGDS, lipocalin type prostaglandin D2 synthase; H-PGDS, hematopoietic type prostaglandin D2 synthase; RBP4, retinol-binding protein-4; PPARγ, peroxisome proliferator-activated receptor-α; CIDEA, cell death-inducing DNA fragmentation factor α-subunit-like effector A; ACOX1, acyl-CoA oxidase 1; PNPLA3, phospholipase domain-containing 3; PEPCK, phospoenolpyruvate carboxykinase; LPL, lipoprotein lipase. Sprague-Dawley rats were treated with control or SRC1 ASO and fed a regular chow diet for 4 wk. Real-time PCR analysis of mRNA expression in the white adipose tissue of hyperinsulinemic euglycemic-clamped rats. P value calculated by Student's t-test.