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Chronic exposure of BDL rats to dark for 1 wk decreases secretin-stimulated cAMP levels in purified cholangiocytes. Basal and secretin-stimulated cAMP levels were evaluated by ELISA. Secretin-induced cAMP levels were ablated in cholangiocytes isolated from BDL + dark rats compared with BDL rats. Data are expressed as means ± SE (n = 6). *P < 0.05 vs. the corresponding basal value of BDL rats.
