Altered gene expression in the intestinal mucosa of TNFAIP3tg mice. Total RNA was extracted from the intestinal mucosa of wild-type (WT) or villin-TNFAIP3 transgenic (TNFAIP3tg) littermates and assessed for gene expression by array. Selected mRNA levels from the complete set of data are shown graphically here. Genes with higher expression in TNFAIP3tg mucosa include indolamine 2,3 dioxygenase (INDO), solute carrier family 30, member 10 (SLC30A10), interferon-γ-inducible protein 47 (ifi47, also known as IRG-47), chemokine ligand 9 (CxCl9), and interferon-γ-induced GTPase (IgtP, also known as IRGM3). Genes with lower expression in TNFAIP3tg mice include pancreatic lipase-related protein precursor (Pnliprp), phospholipase A2 group VIC (Pla2g4c or cytosolic PLA2), intelectin b (itlnb), intelectin 1 (itln1), angiogenin-4 (Ang4), and 5′ nucleotides, ecto (Nt5e or CD73).