Increased Tregs in the colonic mucosa of TNFAIP3tg mice. Colonic lamina propria lymphocytes were isolated and analyzed for the presence of activated CD4 T-lymphocytes (A and B) and FoxP3+ CD4 T lymphocytes (C). Colonic mucosal tissue was assessed for the level of IL-25 (D), IL-23 (E), IL-17 (F), IL-12/23 (G), TSLP (H), IL-22 (I), TNF (J), and IL-10 (K). **P < 0.01.