Fig. 7.

Altered microbiome of colonic mucosal samples in v-TNFAIP3 compared with littermate controls. Comparison between taxonomical population proportions of v-TNFAIP3 vs. littermate controls at both the phylum (A) and order (B) levels. Pie charts depict average proportions for N = 4 mice per group; significant differences were observed between Bacteroidetes and Firmicutes (A) and Bacteriodales and Lachnospiraceae (B), respectively. Tabular results of a 2-way ANOVA with multiple comparisons are also shown. α-Diversity metrics, phylogenetic diversity (PD) tree, Shannon and Simpson are also shown comparing between groups (C) as is β-diversity as assessed by principal coordinate analysis (PCoA) (D).