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. 2014 Aug 29;307(9):H1288–H1297. doi: 10.1152/ajpheart.00068.2014

Fig. 1.

Fig. 1.

Effect of temperature with and without vanilloid-type transient receptor potential (TRPV) family and TRPV4-specific inhibition [ruthenium red (RR) and RN-1734, respectively] on α1 [phenylephrine (PE)]- and α2 [dexmedetomidine (DEX)]-induced adrenergic vasocontraction. A: effect of temperature and RR on PE concentration-response curve. B: effect of temperature and RR on DEX concentration-response curve. C: effect of temperature and RN-1734 on PE concentration-response curve. D: effect of temperature and RN-1734 on DEX concentration-response curve. *Response to concentration significantly different than same concentration in the 37°C control condition (P < 0.05). †Concentration-response curve significantly different than 37°C control curve (P < 0.05).