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. 2014 Oct 14;3(10):e202. doi: 10.1038/mtna.2014.50

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Copyright © 2014 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Total sulfated GAG content and chondroitin sulfate expression are not significantly different in CLN2 knockout versus normal brain tissue. (a) GAG extracts from either whole brain or brain vasculature were prepared from CLN2 knockout and control heterozygote mice and GAG concentrations were measured using Farndale reagent. As an assay positive control, KO tissue was spiked with 50 μg/ml chondroitin sulfate C before processing (Spiked KO Brain). N = 3 for all conditions except the Spiked KO (N = 1); error bars are mean ± SEM. *P value ≤0.05. (b) Tissue sections from forebrain of age-matched CLN2 knockout and control heterozygote mouse brain immunostained for chondroitin sulfate. Scale bar is 250 μm.