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. 2014 Oct 28;3(10):e206. doi: 10.1038/mtna.2014.57

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Copyright © 2014 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/

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Accumulation of lysosomal glycogen is abated in skeletal muscle of Pompe mice treated with GS-PPMO. Glycogen levels in the (a) quadriceps, (b) diaphragm, (c) heart, and (d) liver of Pompe and wild-type mice were measured using the amplex red assay described in the Materials and Methods. Data represent mean ± SEM, n = 9–10 mice per group as indicated in the Materials and Methods. Dashed line represents mean glycogen level of wild-type mice. P < 0.05, (*) compared to WT, (^) compared to vehicle, (#) compared to rhGAA, ($) compared to GS-PPMO at 15 mg/kg.