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. 2014 Oct 22;3(10):e75. doi: 10.1038/emi.2014.75

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Replication of MDk/W452(H5N8) in mammalian animal models. Virus replication was examined in mice, ferrets, dogs and cats that had been experimentally inoculated intranasally with 10⁶ EID₅₀/mL of designated virus. Mouse lung titers shown are means±SD from three animals (A). Individual nasal wash titers are shown for ferrets inoculated with MDk/W452(H5N8) (B), En/W149(H5N1) (C) or MDk/W401(H5N1) (D). To examine transmission, the inoculated animals were individually paired with a DC and an RD-contact animal (1∶1∶1 setup, triplicate). Three infected dogs (E) and cats (F) were also individually cohoused with contact animals in the same cage at 1 dpi and monitored for virus shedding in nasal swabs. The limit of virus detection was 0.7 log₁₀EID₅₀/mL; titers below that limit are shown as 0.5 log₁₀EID₅₀/mL (dashed lines). An asterisk (*) signifies seroconversion as determined by HI analysis at 21 dpi. Inf, directly infected animal.