Table 1. Viral tissue titers in experimentally inoculated animalsa.
| Tissue | MDk/W452(H5N8) | En/W149(H5N1) | MDk/W401(H5N1) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chicken | Duck | Mouse | Ferret | Chicken | Duck | Mouse | Ferret | Chicken | Duck | Mouse | Ferret | |||||||||||||
| 3db | 5d | 3d | 5d | 3d | 5d | 3d | 5d | 3d | 5d | 3d | 5d | 3d | 5d | 3d | 5d | 3d | 5d | 3d | 5d | 3d | 5d | 3d | 5d | |
| Lung | 6.5 ±0.1c | 5.0±0.2 | 5.0±0.3 | 4.0±0.1 | 2.6±0.3 | 3.0±0.4 | 2.0±0.2 | 2.5±0.3 | 6.0±0.3 | 6.5±0.4 | 6.0±0.3 | 6.5±0.1 | 6.0±0.2 | 6.25±0.2 | 5.0±0.3 | 4.0±0.3 | 5.3±0.1 | 6.0±0.4 | 5.5±0.2 | 6.5±0.3 | 4.8±0.4 | 4.1±0.1 | 3.7±0.1 | 2.5±0.1 |
| Brain | 3.5±0.4 | — | — | — | — | 2 | 1±0.1 | 1.0 | 4.0±0.2 | 4.5±0.2 | 4.0±0.2 | 5.0±0.2 | 3.7±0.3 | 3.0±0.1 | — | — | 3.3±0.2 | 4.0±0.3 | 1.5 | 4.5±0.2 | 3.0±0.2 | 2 | — | — |
| Kidney | 5.5±0.2 | 3.0±0.2 | 3±0.2 | 3.5±0.2 | — | — | — | — | 3.0±0.2 | 3.0±0.2 | 3.5±0.2 | 4.0±0.1 | 1.5±0.1 | 1.0±0.1 | 2.5±0.2 | 1.5 | 1.5±0.1 | 2.0±0.1 | 2.5±0.2 | 3.5±0.2 | 3.5±0.3 | 2.5±0.1 | — | — |
| Spleen | 3.5±0.2 | — | 3.5±0.1 | 1.5 | — | — | — | 1.0±0.1 | 1.5±0.1 | 2.0±0.1 | 3.5±0.1 | 4.5±0.2 | 1.5±0.1 | 1.0±0.1 | 2.0±0.1 | 1 | 2.5±0.2 | 3.0±0.2 | 2.3±0.1 | 4.0±0.1 | 1.0±0.1 | — | — | — |
| Heart | 6.5±0.3 | 2.5±0.1 | 5±0.3 | 2.75±0.1 | — | — | — | — | 2.5±0.1 | 3.0±0.1 | 4.5±0.2 | 5.5±0.3 | 2.5±0.2 | 1.5±0.3 | — | — | 2.5±0.3 | 3.0±0.1 | 3.5±0.2 | 5.0±0.3 | 1.5±0.1 | 1.0±0.2 | — | — |
| Liver | 1.5d | — | 3.5±0.2 | — | — | — | — | 1.5 | 2.5±0.2 | 1.5±0.2 | 4.0±0.2 | 2.5±0.1 | 2.5 | — | — | — | 1.5±0.1 | — | 3.0±0.1 | — | 1.5 | — | — | — |
| Colon | 2.5±0.1 | 2.75±0.2 | 4±0.3 | 3±0.3 | — | — | — | 1.5 | 5.3±0.4 | 5.5±0.3 | 6.5±0.3 | 6.5±0.2 | 2.0±0.1 | 1.0±0.1 | — | — | 5.3±0.4 | 5.5±0.2 | 6.5±0.3 | 6.5±0.3 | 1.5±0.2 | 1.0±0.1 | — | — |
Dashed lines indicate that the tissue was negative for virus detection (lower limit=0.7 log10EID50/g).
a
Results were obtained from three animals per group at each time point and are expressed as log10 EID50/g tissue.
b
Day.
c
Standard deviation titers.
d
Positive detection in one animal.