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. 2014 Nov 3;4:6885. doi: 10.1038/srep06885

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(A) Diagram explaining the Tet-On system. (B) Modified Atoh1-CreER-IRES-hPLAP-SV40 Intron- polyadenylation construct⁸ showing replacement of the CreER sequence with the 3G rtTA sequence. Representative alkaline phosphatase (AP) staining images of F10 and F26 showing the presence of the Atoh1-rtTA transgene in the apical turn of the P0 cochlea (C, E) and utricle (D, F). (C′ and E′) High magnification images of region labeled by the black squares in (C) and (E). Scale bars: 100 μm in (C–F) and 20 μm in (C′) and (E′). Schematic of the TetO-mCherry (G) and TetO-LacZ (H) reporter alleles.