Table 3.
Lack of enrichment for liver eQTL in GxE SNPs compared to GWAS SNPs
| Dataset | LD blocks: type, n | LD blocks with liver eQTL (%) | p |
|---|---|---|---|
| All cardiometabolic traits |
nonGxE GWAS, 549 |
35 (6.4) |
0.26 |
| |
GxE, 178 |
9 (5.1) |
|
| HDL-C |
nonGxE GWAS, 69 |
8 (11.6) |
0.21 |
| |
GxE, 43 |
3 (7.0) |
|
| LDL-C |
nonGxE GWAS, 54 |
6 (11.1) |
0.32 |
| |
GxE, 37 |
3 (8.1) |
|
| Triglyceride |
nonGxE GWAS, 45 |
7 (15.6) |
0.08 |
| |
GxE, 35 |
2 (5.7) |
|
| Total cholesterol |
nonGxE GWAS, 55 |
10 (18.2) |
0.02 |
| GxE, 33 | 1 (3.0) |
p-value based on two-sample z-test.