Table 4.
Potential regulatory miRNAs involved in allele-specific miR-mRNA interactions showing GxE interactions
| SNP | Lead SNP | Gene | miRSNP confidence score | Potential regulatory miRNAs* | Cardiometabolic GxE, phenotype-environmental factor |
|---|---|---|---|---|---|
| rs1063539 |
rs1063539 |
ADIPOQ |
5 |
miR-593-3p |
Obesity-PUFA, N-3, DHA + EPA, percent in erythrocyte membranes |
| rs12817689 |
rs2302706 |
MMAB |
7 |
miR-33b-3p, miR-371a-3p, miR-371b-3p, miR-515-3p, miR-519e-3p |
HDL-C-carbohydrate intake |
| rs1491235 |
rs1800591 |
MTTP-TRMT10A |
5 |
miR-33b-5p |
APOB-48 in VLDL-high-fat challenge; cholestanol/mol cholesterol, serum, fasting-diet; cholesterol in VLDL-high-fat challenge; ΔLDL-C-SFA, percent energy from; lathosterol/mol cholesterol, serum, fasting-diet; sitosterol/mol cholesterol, serum, fasting-diet |
| rs3734254 |
rs2076167 |
PPARD |
11 |
miR-885-3p |
ΔHDL-C-physical activity; Δwork output, max-physical activity |
| rs4225 |
rs5070 |
APOC3 |
6 |
miR-885-3p |
HDL-C-fat, total intake; HDL-C-SFA intake |
| rs4707436 |
rs1049353 |
CNR1 |
12 |
miR-593-5p, miR-885-5p |
Δcholesterol, total-MUFA, percent energy from; Δcholesterol, total-PUFA, percent energy from; ΔIL6, plasma-physical activity during energy restriction; ΔLDL-C-MUFA, percent energy from; ΔLDL-C-PUFA, percent energy from; Δleptin, plasma-physical activity during energy restriction; Δresistin, plasma-physical activity during energy restriction; ΔTNF, plasma-physical activity during energy restriction |
| rs4998 |
rs4994 |
ADRB3 |
6 |
miR-593-5p, miR-885-3p |
BMI-energy intake; Δfat mass-physical activity; Δlean mass-physical activity; obesity-physical activity; triglyceride-low-calorie diet |
| rs5446 |
rs5443 |
GNB3 |
10 |
miR-33b-3p, miR-371a-3p, miR-371b-3p, miR-515-3p, miR-519e-3p |
BMI-physical activity |
| rs7021 | rs709592 | PSMD3 | 9 | miR-33b-3p, miR-371a-3p, miR-515-3p, miR-519e-3p | Glucose, fasting-carbohydrate, percent energy from; glucose, fasting-MUFA, percent energy from; insulin resistance (HOMA-IR)-carbohydrate, percent energy from |
text should read as follows: Across all miRSNP data, the maximum confidence score was 24, and for this analysis that range was 0-13, with a higher score indicating higher confidence in the miR regulatory function.
*All miRs listed contain the prefix hsa-.