Table 5.

Plasma cholesterol-induced lesion networks are enriched for cardiometabolic GxE genes

Network, number of genes*	Genes shared with GxE catalog †	Genes shared with GWAS catalog ‡	Enrichment in GxE catalog, p -value
Plasma cholesterol-lowering, 2697	32	80	< 0.001
Regression-reactive, 6096	55	174	< 0.001

*All genes comprising each network, as described [88].

^†GxE genes supporting commonly measured phenotypes and involving common environmental modifiers, n =108.

^‡GWAS genes supporting associations with cardiometabolic phenotypes, n =519.

p-value based on two-sample z-test.