Table 1.

Initial and final body weights and blood glucose concentrations in control and diabetic wild-type and poly(ADP-ribose) polymerase-1-deficient mice.

Variable Group	Body weight (g)		Blood glucose (mmol/l)
	Initial	Final	Initial	Final
PARP-1+/+, C	24.2 ± 0.4	31.2 ± 1.0	6.7 ± 0.1	7.1 ± 0.3
PARP-1+/+, D	24.3 ± 0.5	25.6 ± 0.5**	14.6 ± 0.6**	26.2 ± 0.9**
PARP-1−/−, C	29.9 ± 1.0	35.5 ± 2.0	6.6 ± 0.2	7.3 ± 0.3
PARP-1−/−, D	30.6 ± 1.1	25.8 ± 0.7**	13.8 ± 0.6**	26.8 ± 1.7**

Initial and final blood glucose concentrations were measured after confirmation of diabetes (after 7–8 daily consecutive streptozotocin injections [33]) and at the 12-wk time point, respectively. Data are expressed as Means SEM. n = 10–15 per group. C – control mice; D–diabetic mice; PARP-1 – poly(ADP-ribose) polymerase-1.

^**p < 0.01 vs corresponding non-diabetic groups.