Table 2.

Water intake, urination volume, urinary albumin, total protein and creatinine excretions, albumin-to-creatinine and protein-to-creatinine ratios in control and diabetic wild-type and poly(ADP-ribose) polymerase-1-deficient mice.

Variable Group	PARP-1+/+, C	PARP-1+/+, D	PARP-1−/−, C	PARP-1−/−, D
Water intake (ml)	4.6 ± 1.5	28.5 ± 5.2**	6.1 ± 1.7	16.3 ± 6.0**, ##
Urination volume (ml)	0.53 ± 0.14	20.8 ± 4.4**	1.26 ± 0.40	10.7 ± 3.2**, ##
Albuminuria (μg 48 h−1)	14.8 ± 4.2	314 ± 45**	15.5 ± 6.9	200 ± 53**, #
Proteinuria (mg 48 h−1)	22.0 ± 5.0	317 ± 41**	28.5 ± 7.1	203 ± 51**,#
Creatinine excretion (mg/48 h−1)	255 ± 44	3,187 ± 473**	287 ± 38	3,517 ± 570**
UA/CR (μg/mg)	0.09 ± 0.01	0.16 ± 0.02**	0.09 ± 0.01	0.12 ± 0.01**,#
UP/CR (mg/mg)	0.05 ± 0.01	0.15 ± 0.02**	0.08 ± 0.01	0.11 ± 0.01**,#

Data are expressed as Means ± SEM. n = 7–15 per group. C – control mice; D – diabetic mice; PARP-1 poly(ADP-ribose) polymerase-1; UA/CR – urinary albumin-to-creatinine ratio; UP/CR – urinary protein-to-creatinine ratio.

^**p < 0.01 vs corresponding non-diabetic groups;

^#,##p < 0.05 and < 0.01 vs diabetic wild-type mice.