Table 2.

Relationship Between Adherence to Placebo and Various Events, High Compared to Low Adherence, WHI Clinical Trial Placebo Arm (N=13,444 Women)

Outcome	Adherence Category	Events	Ann %	Crude Hazard Ratio (95% CI)	Adjusted* Hazard Ratio (95% CI)
Death (all cause)	<80%	109	0.99	1.00	1.00
	≥80%	355	0.59	0.65 (0.52, 0.80)	0.64 (0.51, 0.80)
Hip Fracture	<80%	28	0.25	1.00	1.00
	≥80%	99	0.16	0.68 (0.44, 1.03)	0.50 (0.33, 0.78)
Clinical Vertebral fracture	<80%	21	0.19	1.00	1.00
	≥80%	106	0.18	0.92 (0.58, 1.48)	0.79 (0.49, 1.27)
Distal forearm/wrist fracture	<80%	78	0.53	1.00	1.00
	≥80%	475	0.63	1.18 (0.93, 1.50)	1.08 (0.85, 1.38)
Clinical MI	<80%	50	0.46	1.00	1.00
	≥80%	191	0.32	0.73 (0.53, 0.99)	0.69 (0.50, 0.95)
CHD Death	<80%	19	0.17	1.00	1.00
	≥80%	70	0.12	0.75 (0.44, 1.25)	0.82 (0.48, 1.40)
Any Cancer	<80%	138	1.32	1.00	1.00
	≥80%	726	1.24	0.94 (0.79, 1.13)	0.91 (0.76, 1.10)
Invasive breast cancer	<80%	50	0.46	1.00	1.00
	≥80%	215	0.36	0.76 (0.56, 1.04)	0.73 (0.53, 1.00)
Colorectal cancer	<80%	14	0.13	1.00	1.00
	≥80%	105	0.17	1.36 (0.78, 2.38)	1.41 (0.80, 2.48)
Cancer death	<80%	52	0.47	1.00	1.00
	≥80%	163	0.27	0.62 (0.45, 0.85)	0.60 (0.43, 0.82)

CHD = coronary heath disease; MI = myocardial infarction; Ann % = Annualized %

^*Adjusted for age, ethnicity, education, smoking, alcohol, fruit/vegetables intake, red meat intake, BMI, physical activity, physical function, any insurance, mammogram, visit to usual care provider in the past year, colonoscopy ever, family history of fracture, family history of breast cancer, self-reported health, history of diabetes, bilateral oophorectomy, age at first birth, age at menarche, depression, aspirin, corticosteroids, fracture medication, beta blockers, thiazides, loop diuretics, PPIs, NSAIDs, lifetime hormone therapy duration, number of medications taken