Table 3.

Relationship Between Adherence to Placebo and Adherence to Other Medications, WHI HT Clinical Trial Placebo Arm Women

Cumulative Adherence † to placebo	Statin Users* (n = 883)				Osteoporosis Drug** Users* (n = 158)
	N	Persistent ***	Non- Persistent	Missing	N	Persistent ***	Non- Persistent	Missing
≥ 80%	708	82%	17%	2%	132	70%	29%	1%
< 80%	175	63%	21%	15%	26	50%	35%	15%
p value, Fisher's exact test	<.001				<.001

Data shown are % in each row

Differences in persistence for both statin use and osteoporosis drug use are statistically different between women adherent vs. non-adherent to placebo by Fisher’s exact test, p < 0.001 for each

^*A user is defined as someone taking this medication at baseline

^**Osteoporosis drugs include bisphosphonates, raloxifene, and calcitonin

^***Persistent is defined by continued use to one year after baseline

^†Evaluated one year after baseline