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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Chem Sci. 2014 Apr 2;5(6):2311–2317. doi: 10.1039/C4SC00484A

Figure 1.

Figure 1

(A) Images of BMS-378806 (1) and first-generation ARM-H (2). (B) Crystal structure of CD4 bound to HIV gp120 HIV-1 gp120 (PDB 1G9N). CD4 F43 (light blue) engages conserved hydrophobic residues V255, E370, W427, T257 and M475 of gp120 (pink) as well as W112, F382 (orange), which cap a hydrophobic accessory pocket lined by F210, L116, Y435, V255 and V208 (dark blue).