. Author manuscript; available in PMC: 2015 Jun 1.

Published in final edited form as: Chem Sci. 2014 Apr 2;5(6):2311–2317. doi: 10.1039/C4SC00484A

Table 3.

Activity profile of compounds 1, 7, and 9 against a panel of laboratory-derived HIV-1 gp120 pseudotyped viruses in TZM-bl cells (Clade A = green, Clade B = blue, Clade C = red). VSV-G is a non-specific viral glycoprotein control. Value are representative of triplicate data and assay repeated least 2 times for each compound and pseudotype. ‘NT’ = not tested.

pseudotype	1 IC₅₀ (nM)	7 IC₅₀ (nM)	9 IC₅₀ (nM)
JR-FL	45	0.2	1.5
ADA	246	0.14	6.3
HXBc2	32	0.12	10.3
BaL	NT	0.01	34.8
LAI	45	0.1	4.3
YU2	358	0.43	14.6
11500	>1000	2.1	165
11502	>1000	0.73	2.8
11506	>1000	0.11	8.0
11528	>1000	0.19	5.0
VSV-G	>1000	>1000	>1000