Table 1. Protein mimetic peptides and their function.
Sequence | Mimicked protein | Associated integrin | Cell line | Observed cell response | Reference |
RGD | Fibronectin, Collagen I, Laminin α1, Vitronectin | αVβ3 a | Human pulmonary fibroblast | Adhesion | 17 |
Human skin fibroblast | Collagen I synthesis | 105 | |||
104,137–139 | VIC | Adhesion | 77 | ||
Human periodontal ligament fibroblast | Adhesion | 140 | |||
GFOGER-(POG)n | Collagen I | α2β1, α1β1 | Human dermal fibroblast | Collagen I synthesis | 141 |
23,142 | |||||
DGEA | Collagen I | α2β1, α3β1 | Human pulmonary fibroblast | Adhesion | 17 |
143 | 143 | ||||
YIGSR | Laminin β1 | α3β1, α4β1, α6β1 | Human periodontal ligament fibroblast | Adhesion | 106 |
144 | Human dermal fibroblast | Adhesion | 140 | ||
IKVAV | Laminin α1 | α3β1, α4β1, α6β1 | Human pulmonary fibroblast | Adhesion | 17 |
144 | Human periodontal ligament fibroblast | Adhesion | 140 | ||
PHSRN(SG)5RGDSP | Fibronectin | α5β1 | 3T3 fibroblasts | Adhesion | |
104,138 | |||||
P15 | Collagen I | α2β1 | VIC | αSMA expression | 77 |
73 | 73 | ||||
VGVAPG | Elastin | affinity binding protein | VIC | αSMA expression | 77 |
73 |
aMost strongly bound amongst several integrins, which include α5β1, α8β1, αvβ1, αvβ5, αvβ6, & αvβ8.