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. 2014 Mar 5;2(5):634–650. doi: 10.1039/c3bm60319a

Table 1. Protein mimetic peptides and their function.

Sequence Mimicked protein Associated integrin Cell line Observed cell response Reference
RGD Fibronectin, Collagen I, Laminin α1, Vitronectin αVβ3 a Human pulmonary fibroblast Adhesion 17
Human skin fibroblast Collagen I synthesis 105
104,137–139 VIC Adhesion 77
Human periodontal ligament fibroblast Adhesion 140
GFOGER-(POG)n Collagen I α2β1, α1β1 Human dermal fibroblast Collagen I synthesis 141
23,142
DGEA Collagen I α2β1, α3β1 Human pulmonary fibroblast Adhesion 17
143 143
YIGSR Laminin β1 α3β1, α4β1, α6β1 Human periodontal ligament fibroblast Adhesion 106
144 Human dermal fibroblast Adhesion 140
IKVAV Laminin α1 α3β1, α4β1, α6β1 Human pulmonary fibroblast Adhesion 17
144 Human periodontal ligament fibroblast Adhesion 140
PHSRN(SG)5RGDSP Fibronectin α5β1 3T3 fibroblasts Adhesion
104,138
P15 Collagen I α2β1 VIC αSMA expression 77
73 73
VGVAPG Elastin affinity binding protein VIC αSMA expression 77
73

aMost strongly bound amongst several integrins, which include α5β1, α8β1, αvβ1, αvβ5, αvβ6, & αvβ8.