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University of California San Francisco Criteria for Probable CJD
| Clinical Symptoms |
|---|
| Rapid cognitive decline with any two of: |
| Myoclonus |
| Pyramidal/extrapyramidal |
| Visual |
| Cerebellar |
| Akinetic mutism |
| Other focal cortical signs |
|
|
| AND Diagnostic Testing |
|
|
| Typical MRI changes on FLAIR and DWI |
| EEG findings of periodic sharp and wave complexes |
|
|
| AND No other condition to explain observed clinical findings |
Modified from Geschwind, Continuum, 2010
