Figure 5. Human adipose stem cells and pancreatic ductal epithelial cells are comparatively resistant to nCIN elevation in the presence of NMS-P715. A, D.

Cells were hybridized with chromosome X or 17 centromeric probes following 72h exposure to NMS-P715 at the indicated concentrations or vehicle control. %MD was calculated as before (Fig. 3). *p≤0.037 (paired t-test). B. After treatment, cells were plated at 400 cells per well in triplicate in 12 well dishes and incubated for 6 days (PANC-1) or 7 days (ASCs) in compound-free medium to determine effects on cell growth. Percent growth inhibition of cells was determined relative to controls using a colorimetric assay (see Supplementary Fig. S6). C. Western analysis of ASC3 and ASC4 cells as outlined in Fig. 2A.