Table 2.

Different heat shock proteins, their localization, functions, and involvement in different neurodegenerative diseases.

HSPs	MW (kDa)	Localization	Colocalization	Functions	Involved in diseases
HSP10	10	Mitochondria, cytosol, ER, and nucleus	Aβ	Protein folding	AD, MS, and tauopathies
HSP27	20–30	Cytosol, ER, and nucleus	Tau, Aβ, HTT, and α-synuclein	Protein degradation	AD, HD, and PD
HSP40	40	Cytosol	HTT and α-synuclein	Protein folding	HD and PD
HSP60	60	Mitochondria	Aβ	Prevent protein aggregation	AD
HSP70	70	Cytosol, ER, nucleus, and mitochondria	Aβ, HTT, α-synuclein, and PrPc	Protein folding/unfolding	AD, HD, PD, Prion, and MS
HSP90	90	Cytosol and ER	Aβ, HTT, α-synuclein, and PrPc	Protein degradation and transcription factor	AD, PD, and HD
HSP104/110	100–110	Cytosol and ER	α-synuclein and PrPc	Thermal tolerance	PD and prion