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Effect of weight loss and exercise intervention on DNAm age. For 21 subjects, liver methylation data were available before and after bariatric surgery. As expected, BMI drops significantly within 6–9 mo following bariatric surgery (A). However, the DNAm age of the liver tissue is unaffected (B). (C) DNAm age of adipose tissue is unaffected by a 6-mo exercise intervention (20).
