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Pedigree of LFL kindred MM. Proband (III:4) was diagnosed with rhabdomyosarcoma at the age of 29 mo. III:2 had succumbed to a brain tumor at age of 32 mo. I:1 died at 55 y of age from breast cancer. The remaining family members are cancer-free. All members with validated mutation in TP53 are denoted with a dot. The family members II:6, II:7, III:1, III:3, and III:4 were selected for WES and aCGH.
