Changes in ABC subscores for irritability, lethargy, stereotypy, and hyperactivity. After 4, 10, and 18 wk of treatment with sulforaphane or placebo, and a 4-wk untreated recovery period (22 wk). Raw, unadjusted mean values of changes (±SEM) for sulforaphane- and placebo-treated participants are shown. Changes were significant at the 95% confidence level (*) for both irritability and lethargy at 10 and 18 wk of treatment.