Table 3.
Early response genes in Caco-2 cells after exposure to curcumin.
| Fold change (treated/control) | |||||||
| 30 μmol/L | 100 μmol/L | ||||||
| Accession number | Gene Name | Gene Symbol | 3 h | 6 h | 3 h | 6 h | Involved in |
| AA418907 | cytochrome P450, family 1, subfamily A, polypeptide 1 | CYP1A1 | -2.93 | -3.00 | -2.89 | -6.39 | Xenobiotic metabolism |
| R93124 | aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1) | AKR1C1 | 1.05 | 1.60 | -1.15 | 1.18 | Xenobiotic metabolism |
| AA486533 | early growth response 1 | EGR1 | 1.11 | 1.03 | 2.49 | 2.30 | Gene transcription |
| AA452909 | nuclear receptor subfamily 2, group F, member 1 | NR2F1 | -1.40 | NA1 | -1.20 | 1.83 | Gene transcription |
| N94487 | nuclear receptor subfamily 4, group A, member 1 | NR4A1 | -1.19 | 1.09 | 1.45 | 1.08 | Gene transcription |
| AA448256 | metal-regulatory transcription factor 1 | MTF1 | 0.28 | 0.34 | 0.09 | 0.74 | Gene transcription |
| T61948 | FBJ murine osteosarcoma viral oncogene homolog B | FOSB | -1.37 | 1.21 | -1.22 | -1.62 | Gene transcription |
| AA599176 | heterogeneous nuclear ribonucleoprotein A0 | HNRPA0 | -1.05 | -1.31 | -1.12 | -1.58 | Gene transcription |
| AA733038 | polymerase (RNA) I polypeptide C, 30 kDa | POLR1C | -1.22 | -1.28 | -1.34 | -1.73 | Gene transcription |
| AA464970 | phospholipase C, beta 2 | PLCB2 | NA | 1.93 | 1.08 | 1.05 | Signal transduction |
| AA450205 | translocation protein 1 | TLOC1 | 1.15 | -1.36 | -1.20 | -1.62 | Protein transport |
| AA419177 | solute carrier family 7, member 5 | SLC7A5 | -1.27 | -1.54 | -1.56 | -1.99 | Transport |
| AA425451 | integrin, alpha E | ITGAE | NA | 1.43 | 1.54 | NA | Cell adhesion |
| AA888148 | tubulin, beta 2 | TUBB2 | -1.25 | -1.25 | -1.57 | -1.97 | Cytoskeleton |
| AA496359 | immediate early protein | ETR101 | -1.09 | -1.02 | 1.77 | 1.52 | unknown |
1 NA: not available