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PAI-1 latency transition. (Left) In the active state, the RCL is solvent-exposed and s1C is hydrogen-bonded to β-sheet C. (Right) The active state contrasts with the latent state, where s1C is released from sheet C and the RCL is inserted into β-sheet A as the fourth strand in a now six-stranded, fully antiparallel β-sheet. The sequence of the RCL and s1C is shown below the structures. h, helix; s, strand.
