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Drug candidate AZ3976 binds to the DRP prelatent state structure. The DRP prelatent structure for WT PAI-1 (green) is superimposed on the X-ray crystal structure of latent PAI-1 (gray) bound to the small-molecule inhibitor AZ3976 (blue) [PDB ID code 4AQH (5)]. AZ3976 (red) is shown in the top-scoring position found by docking to the DRP prelatent structure using Autodock (47). (Right) Region containing AZ3976 is enlarged.
