Table 1.
Summary of patients initially identified (n = 41).
| Age | Gender | Time to LM | Pathology (at time of LM) | Treatment | Time to progression | Time to death | Died? |
|---|---|---|---|---|---|---|---|
| 39 | f | 24.2 | GBM | None | NA | 0.1 | No |
| 47 | m | 2.8 | GBM | None | NA | 0.4 | Yes |
| 53 | m | 5.0 | GBM | i.t.+RT | 0.8 | 1.2 | NA |
| 58 | f | 3.9 | GBM | None | NA | 1.3 | Yes |
| 58 | m | 8.5 | GBM | None | NA | 1.4 | No |
| 15 | m | 27.1 | GBM | None | 0.8 | 2.1 | Yes |
| 41 | m | 14.5 | GBM | None | NA | 3.3 | Yes |
| 20 | m | 7.9 | GBM | i.t. + CT + RT | 1.3 | 4.1 | Yes |
| 51 | f | 16.4 | GBM | RT | NA | 4.5 | NA |
| 42 | m | 141.3 | GBM | CT | 5.0 | 5.9 | No |
| 56 | m | 69.5 | GBM | i.t. + CT | NA | 6.4 | Yes |
| 57 | m | 5.1 | GBM | CT | 1.4 | 7.4 | Yes |
| 66 | f | 5.6 | GBM | None | 3.9 | 7.8 | Yes |
| 57 | f | NA | GBM | CT + RT | 2.4 | 8.8 | Yes |
| 59 | m | 16.3 | GBM | sx + i.t. | 7.4 | 9.7 | Yes |
| 53 | m | 7.8 | GBM | CT + RT | 4.7 | 9.9 | Yes |
| 50 | f | 8.2 | GBM | CT | 9.1 | 10.0 | Yes |
| 32 | f | 5.1 | GBM | i.t. + CT | 5.3 | 10.2 | Yes |
| 62 | m | 3.2 | GBM | CT | 5.5 | 11.7 | Yes |
| 26 | m | NA | GBM | NA | NA | 13.6 | Yes |
| 23 | f | 45.2 | GBM | CT + RT | 9.0 | 14.4 | Yes |
| 47 | m | 0.0 | GBM | RT | 1.6 | 14.7 | Yes |
| 55 | f | NA | GBM | CT + RT | 6.3 | 20.2 | Yes |
| 19 | f | 4.9 | GBM | RT | 6.9 | 23.5 | Yes |
| 41 | m | 39.6 | GBM | i.t. + RT + CT | 4.4 | 32.3 | Yes |
| 31 | m | 65.4 | AOA | None | NA | 1.0 | No |
| 32 | f | 91.7 | AO | i.t. + RT | 1.4 | 2.2 | No |
| 32 | f | 92.1 | AO | i.t. | NA | 2.4 | No |
| 33 | m | 18.0 | AG | CT | 3.0 | 4.7 | Yes |
| 41 | m | 43.9 | AOA | i.t. + CT | NA | 6.2 | Yes |
| 19 | m | 10.0 | AA | NA | NA | 9.1 | No |
| 40 | m | 37.0 | AO | CT | 6.3 | 13.5 | Yes |
| 58 | m | 220.8 | AO | CT + RT | 3.1 | 18.9 | Yes |
| 33 | m | 48.6 | AO | sx + rt + ct | 9.4 | 19.0 | Yes |
| 51 | f | 43.2 | AO | CT | 22.3 | 42.0 | Yes |
| 41 | f | 83.4 | OA | sx + CT | 5.2 | 5.9 | No |
| 51 | m | 21.6 | ME | rt | NA | 38.4 | No |
| 18 | m | NA | EP | CT + RT | 62.8 | 75.0 | No |
| 31 | f | 30.4 | NA | NA | NA | 1.7 | No |
| 35 | f | 39.7 | Astro | CT | 16.6 | 22.5 | No |
| 3 | m | 1.2 | Astro | NA | NA | NA | NA |
Sorted by pathologic grade and then by time to death.
Times are given in months.
Age is at time of first diagnosis.
LM, leptomeningeal metastases.
Pathology: GBM, glioblastoma multiforme; AOA, anaplastic oligoastrocytoma; AO, anaplastic oligodendroglioma; AG, anaplastic glioma (anaplastic PXA vs. anaplastic ganglioglioma); AA, anaplastic astrocytoma; OA, oligoastrocytoma; ME, myxopapillary ependymoma; EP, ependymoma; astro, astrocytic tumor; grade unknown (grade II, III or IV).
Treatment: i.t., intrathecal (via Ommaya); CT, chemotherapy; sx, surgery; RT, radiotherapy (intensity-modulated radiation therapy and/or stereotactic radiosurgery).
NA, not available.