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. Author manuscript; available in PMC: 2014 Nov 3.
Published in final edited form as: Ann Biomed Eng. 2011 Dec 28;40(5):1170–1181. doi: 10.1007/s10439-011-0494-z

Figure 3. Memantine fully protects neurons from an overall loss in SI.

Figure 3

Treatment with different memantine either during or prior to treatment with 300 µM glutamate results in complete protection from the overall loss of synchronization observed in cultures treated with glutamate alone. * = statistically different from control. ***p<0.001 determined by one-way ANOVA followed by Student-Newman-Keuls Multiple Comparison Test. Statistical analysis was performed on a per MEA basis (n=20 for control, n=21 for 300 µM glutamate, n=12 for concurrent 300 µM glutamate and 50 µM memantine treatment, n=12 for pretreatment with 50 µM memantine treatment followed by treatment with 300 µM glutamate).