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. Author manuscript; available in PMC: 2014 Nov 3.
Published in final edited form as: Ann Biomed Eng. 2011 Dec 28;40(5):1170–1181. doi: 10.1007/s10439-011-0494-z

Figure 5. The change in burst duration after glutamate and memantine treatments.

Figure 5

Cultures treated with 300 µM glutamate had a significant increase in average burst duration. Cultures treated with 50 µM memantine at the same time as 300 µM glutamate had no change in the average burst duration. Cultures pretreated with 50 µM memantine prior to glutamate treatment had a significant increase in burst duration. *= statistically different from control. # = statistically different from 300 µM glutamate. ***p<0.001, **p<0.01, *p<0.05 determined by one-way ANOVA followed by Student-Newman-Keuls Multiple Comparison Test. Statistical analysis was performed on a per MEA basis (n=20 for control, n=21 for 300 µM glutamate, n=12 for concurrent 300 µM glutamate and 50 µM memantine treatment, n=12 for pretreatment with 50 µM memantine treatment followed by treatment with 300 µM glutamate).