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. Author manuscript; available in PMC: 2014 Nov 3.
Published in final edited form as: Endocr Relat Cancer. 2012 Apr 10;19(2):111–122. doi: 10.1530/ERC-10-0327

Figure 3.

Figure 3

H and E staining of (A, C, and E) control and (B, D, and F) C57BL/6 homozygous mutant thyroids at different stages, demonstrating that in Pten mutants, the increase in size starts very early during thyroid organogenesis (compare B with A at E15.5). (C–G) At the adult stage, mutant thyroids are enlarged, with multilayered epithelial cells surrounding the colloid lumen. Some follicles are dysmorphic with abnormal material inside. (H) Statistical analysis of the weight of P=14 thyroids (n=10 for mutant and wild-type). p<0.05.