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. Author manuscript; available in PMC: 2014 Nov 3.
Published in final edited form as: Endocr Relat Cancer. 2012 Apr 10;19(2):111–122. doi: 10.1530/ERC-10-0327

Figure 4.

Figure 4

Double IF staining for PH3 (marker for proliferation) and E-cadherin (marker for epithelial cells) as well as quantification of the number of E-cadherin and phosphohistone H3 double-positive cells in control and mutant thyroids at (A–C) E15.5 and (D–F, C57BL/6 background; G–I, BALB/c background) PN14 (n=3 for each group). Note that in the BALB/c background, the increase in epithelial proliferation is not as pronounced compared with the one observed in the C57BL/6 background. Note that for proliferation at E15.5, no differences were observed between both genetic backgrounds. White arrows in B, E and H indicate double positive cells for E-cadherin and phosphohistone H3. p<0.05.