Figure 5. Comparison of binding pockets and intermolecular hydrogen bonding contacts in complexes of c-di-AMP bound to the ydaO riboswitch and the protein DisA.
a, Insertion of both adenine rings of c-di-AMP within pockets in the complex with T. tengcongensis ydaO riboswitch. b, Intermolecular hydrogen bond interactions between c-di-AMP and the RNA in the ydaO riboswitch complex. c, Insertion of both adenine rings of c-di-AMP within pockets in the complex with DisA protein (PDB Code: 3C1Y). d, Intermolecular hydrogen bond interactions between c-di-AMP and the protein in the DisA complex (PDB Code: 3C1Y).