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. Author manuscript; available in PMC: 2014 Nov 3.
Published in final edited form as: Angiol Open Access. 2013 Apr 8;1:17309. doi: 10.4172/2329-9495.1000102

Figure 2.

Figure 2

An aberrant angiogenic signature as a hallmark of angiosarcomas. Angiosarcomas are characterized by major alterations in several key angiogenic processes including disrupted expression of VEGF ligands and their cognate receptors, disrupted expression of angiopoietin ligands and their cognate Tie receptors, reduced expression of thrombospondin 1 (THBS1), and alterations in global transcriptome patterns. Moreover, secondary angiosarcomas are characterized by an enhanced oxidative stress response.