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. 2014 Nov 3;9(11):e108419. doi: 10.1371/journal.pone.0108419

Figure 1. Prediction and mapping strategy of the epitopes in the central region of CCHFV-NP.

Figure 1

(a) Epitope prediction for amino acid residues 237–305 of the NP sequence of the YL04057 strain using DNAStar Protean software. The secondary structure, flexibility plot, hydrophilicity, surface probability, and antigenicity index for NP237−305 were taken into consideration. (b) Epitope predictions of the NP237−305 fragment of the YL04057 strain based on various principles. (c) Schematic of the BCE mapping strategy with six 16–22mer overlapping biosynthetic peptides spanning the NP237−305 fragment. The blue band represents the full length nucleoprotein. The red band represents the immunodominant fragments of YL04057 NP.