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. 2014 Nov 3;9(11):e110934. doi: 10.1371/journal.pone.0110934

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© 2014 Azevedo et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Scatter plot of betweenness centrality versus degree for nodes obtained in the transcriptional network analysis. Differentially expressed (DE) genes are represented as red (up-regulated) or green (down-regulated) diamonds in the graphic. DE-related genes are represented as purple diamonds. (B) Transcriptional interaction subnetwork containing the 25 DE genes and 15 DE-related genes with the highest centrality values in each network. DE genes are represented as red (up-regulated) or green (down-regulated) squares in the networks. DE-related genes are represented as purple diamonds. Genes previously associated with the keywords “Angiotensin II” and “glioma” display yellow border colors. Genes previously associated with the keywords “glioma”, “migration” or “invasion” display sea green border colors. (C) KEGG categories showing enrichment in functions for the hub genes.