Table 5.
mRNA prognostic biomarkers identified in our previous studies7,38,39 ranked as top driver genes in poor prognosis SQCC patients.
| GENE NAME | MODULATOR? (# MODULES)* | MODULATED BY | REFERENCE |
|---|---|---|---|
| SCLY | No | IFRD1 | 39 |
| TNFSF9 | No | CTSB | 38 |
| CD27 | No | STAT4 | 39 |
| DAG1 | No | SELT | N/A# |
| SAMD4B | Yes (3) | No modulator | N/A# |
| THBS1 | No | CTSB | 39 |
| XPO1 | No | PTGER2 | 39 |
| C8orf70 | No | PTGER2 | 39 |
| STK24 | No | CTSB | 39 |
| AKAP13 | No | CTSB | 38 |
| APOA2 | Yes (3) | No modulator | 7 |
| CCL19 | No | STAT4 | 7 |
| CLIC2 | No | STAT4 | 7 |
| COL14A1 | No | VASH1 | 7 |
| HMBOX1 | No | VASH1 | 7 |
| IRF3 | No | SAMD4B | 7 |
| ATAD4 | Yes (5) | No modulator | 7 |
| SLC39A8 | No | VASH1 | 7 |
| APIN1 | No | IFRD1 | 7 |
| TAF4 | No | SELT | 7 |
| TOMM34 | No | CTSB | 7 |
| VASH1 | Yes (2) | SAMD4B | 7 |
| VIPR2 | No | SERPINA3 | 7 |
| HFE | No | IFRD1 | 39 |
| HNF4A | No | CTSB | N/A# |
| STAT6 | No | SERPINA3 | 47 |
Notes:
*
If a gene is a modulator (driver gene), the number of modules regulated by it is listed in parentheses.
#
Unpublished mRNA prognostic biomarkers associated with NSCLC outcome.