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. 2014 Oct 13;13(Suppl 5):1–12. doi: 10.4137/CIN.S14060

Figure 4.

Figure 4

Two potential mechanisms of honokiol regulation of Notch ligands. In the set of 30,347 candidate networks that fit the SW480 data, only 25 (0.08%) networks included honokiol activating Jagged, the node representing Notch ligands in our network. In contrast, 30,044 (99.00%) networks included honokiol inhibiting Jagged. In all networks, IR inhibited Jagged. (A) A representative Notch circuit from the set of candidate networks where honokiol is inhibiting Jagged and (B) a representative circuit from the set of candidate networks where honokiol is activating Jagged are presented. Logic regulations that differ between (A) and (B) are bolded. Black edges with arrows indicate activating regulations and red edges with blunt ends indicate inhibiting regulations.