Table 1.
Frequency of each regulation type in 30,347 candidate networks that fit the SW480 data.
| TARGET NODE | % OF CANDIDATE NETWORKS WITH REGULATION | |
|---|---|---|
| CDK1 | honokiol NOT honokiol NOT P27 NOT P53 P53 |
10.64% 74.65% 94.24% 81.33% 16.99% |
| MYC |
AKT NOT honokiol NOT IR RAS |
84.42% 93.45% 100.00% 76.35% |
| BAX |
honokiol NOT AKT NOT honokiol NOT P53 P53 |
73.32% 86.25% 1.11% 21.95% 78.05% |
| JAGGED | HES-P honokiol NOT HES-P NOT honokiol NOT IR NOT RAS RAS |
29.57% 0.08% 28.41% 99.00% 100.00% 10.88% 42.27% |
| NICD |
honokiol IR JAGGED NOT honokiol NOT IR\ NOT JAGGED |
96.98% 77.36% 99.36% 1.33% 5.03% 0.64% |
| HES-P | hes1-g | 100.00% |
| hes1g | HES-P IR NICD NOT HES-P NOT IR |
48.77% 59.43% 100.00% 27.82% 16.92% |
| RAS |
NOT honokiol RAS serum |
87.24% 4.34% 50.27% |
| AKT | AKT NOT honokiol serum |
0.77% 92.80% 63.07% |
| P27 | HES-P honokiol NOT HES-P NOT MYC P27 |
41.69% 73.84% 33.09% 92.58% 0.05% |
| P53 | honokiol IR MDM2 NOT honokiol NOT IR NOT MDM2 |
21.52% 78.05% 1.39% 0.13% 21.95% 16.54% |
| MDM2 | honokiol MDM2 NOT H NOT P53 P53 |
47.70% 5.96% 30.16% 39.52% 28.63% |
| PROLIF | CDK1 | 100.00% |
| APOP | BAX | 100.00% |
Note: Regulations in bold were included in at least 70% of the networks. The presence of the auto-regulation of a node (eg, AKT by AKT) represents the logic rule that allows for constitutive activation of the node. Regulatory nodes preceded by “NOT” indicate inhibitory regulations of the target node, and all others indicate activating regulations of the target node.