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. 2014 Oct 15;8(6):1772–1776. doi: 10.3892/etm.2014.2023

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Copyright © 2014, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Effect of SB203580 (p38 mitogen-activated protein kinase inhibitor; 10 μM) on lipopolysaccharide (LPS)-induced phosphorylation of signal transducer and activator of transcription-3 (STAT3) activity in MH-S alveolar macrophages. The cells were stimulated with LPS (100 ng/ml) for 15 or 30 min. The cell lysates were collected and the phosphorylated-STAT3 (p-STAT3) activity was measured. Representative results of the two experiments are shown. The levels of p-STAT3 protein exhibited a marked increase 15 min after LPS induction (P<0.05) and peaked at 30 min after treatment. SB203580 treatment almost completely blocked STAT3 phosphorylation even at a concentration of 10 μM.