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. 2014 Oct 17;8(6):1891–1895. doi: 10.3892/etm.2014.2033

Figure 4.

Figure 4

BDNF attenuates Aβ25–35-induced apoptosis and inhibition of SH-SY5Y neuroblastoma cells. (A) Flow cytometry assay was performed to visualize the extent of programmed cell death in the control group. (B) Apoptosis of cells that were administered Aβ25–35 (20 μM). (C) Apoptosis of cells that were administered Aβ25–35 (20 μM) combined with BDNF (10 ng/ml). (D) Apoptosis of cells that were administered Aβ25–35 (20 μM) combined with BDNF (10 ng/ml) and LY294002 (20 μM). M2 represents the population of cells with high annexin V binding. Aβ, β-amyloid; BDNF, brain-derived neurotrophic factor.