Table 3. Analyses of Neonatal Abstinence Score in infants exposed to antidepressants in utero, born at Karolinska University Hospital Huddinge 1 Jan 2007 to 30 June 2009.
All antidepressants | citalopram | sertraline | fluoxetine | Other antidepressants≠ | p | |
Scoring performed (n[%]) | 205 [93%] | 71 [92%] | 71 [93%] | 33 [97%] | 30 [91%] | 0.5† |
Number of scoring occasions | ||||||
(mean [SD] [range]) | 8.4 [3.0] [2–27] | 8.5 [2.7] [3]–[18] | 8.4 [2.9] [2]–[20] | 8.4 [4.4] [2–27] | 8.3 [2.2] [5]–[13] | 0.66†† |
Neonatal abstinence (n[%]) | ||||||
No abstinence | 152 [74%] | 51 [72%] | 53 [75%] | 24 [73%] | 24 [80%] | |
Mild abstinence * | 46 [22%] | 18 [25%] | 16 [23%] | 7 [21%] | 5 [17%] | |
Severe abstinence ** | 7 [3%] | 2 [3%] | 2 [3%] | 2 [6%] | 1 [3%] | 0.85*** |
*two or more scorings of 4–7.
**two or more scorings of 8 or above.
***Multiple ordinal regression, adjusted for infant sex and 5 min Apgar.
Chi square test.
Kruskal Wallis.
other antidepressants (n = 33): escitalopram (13 patients), venlafaxine (11), paroxetine (8) and duloxetine (1).