Table 1. Log ratio values for TLR4 polymorphic/wild type gene expression of components of the TLR signalling pathway under basal conditions.
| Gene symbol | Protein name | Log2 mean ratio TLR4 polymorphic/Wild type (respective fold change) |
| MyD88 dependent genes | ||
| IRAK4 | Interleukin-1 receptor-associated kinase 4 (IRAK4) | −1.13 |
| MAP3K7IP1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB1) | −1.02 |
| NFKBIL2 | Tonsoku-like protein (IKBR) | −1.00 |
| PTGS2 | Prostaglandin G/H synthase 2 (COX-2) | −2.11 |
| RELA/p65 | NF-κB subunit p65 | −1.02 |
| RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 (RIP2) | −1.35 |
| SITPEC | Evolutionarily conserved signalling intermediate in Toll pathway (ECSIT) | −1.00 |
| Trif dependent genes | ||
| IRF1 | Interferon regulatory factor 3 (IRF1) | −1.10 |
| IRF3 | Interferon regulatory factor 3 (IRF3) | −1.21 |
| TBK1 | Serine/threonine-protein kinase TBK1 | −1.03 |
| TICAM2 | TIR domain-containing adapter molecule 2 (TRAM) | −1.06 |
| Non pathway specific genes | ||
| CD14 | Monocyte differentiation antigen (CD14) | +1.02 |
| CSF3 | Granulocyte colony-stimulating factor (G-CSF) | −2.97 |
| IL-12B | Interleukin 12B | −1.07 |
| IL2 | Interleukin 2 | −1.2 |
| PGLYRP3 | Peptidoglycan recognition protein 3 | −1.05 |
| TLR5 | Toll like receptor 5 | −1.03 |
| TLR7 | Toll like receptor 7 | −1.11 |
| TLR8 | Toll like receptor 8 | −1.02 |
| TLR9 | Toll like receptor 9 | −1.04 |
| UBE2N | Ubiquitin-conjugating enzyme E2 | −1.03 |
A value of −1 is equivalent to a 2 fold increase in gene expression in wildtype subjects compared to TLR4 polymorphic subjects. A value of +1 is equivalent to a 2 fold decrease in gene expression in TLR4 polymorphic subjects compared to wild type. All fold changes presented were statistically significant with p value <0.05.