Table 2. Log ratio values TLR4 polymorphic/wild type following stimulation with E. coli LPS.
| Gene symbol | Protein name | Log2 mean ratio TLR4 polymorphic/Wild type (respective fold change) |
| MyD88 dependent genes | ||
| CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) | −1.14 |
| IRAK2 | Interleukin-1 receptor-associated kinase 2 (IRAK2) | −1.17 |
| IRAK4 | Interleukin-1 receptor-associated kinase 4 (IRAK4) | −1.21 |
| MAP2K4 | Mitogen-activated protein kinase kinase 4 | −1.22 |
| MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | −1.20 |
| MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | −1.08 |
| MAP3K7IP1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB1) | −1.29 |
| MAP3K7IP2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2) | −1.10 |
| MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4 | −1.11 |
| MAPK10 | Mitogen-activated protein kinase 10 | −1.09 |
| MAPK12 | Mitogen-activated protein kinase 12 | −1.13 |
| MAPK14 | Mitogen-activated protein kinase 14 | −1.19 |
| NFKBIL2 | Tonsoku-like protein (IKBR) | −1.33 |
| PTGS2 | Prostaglandin G/H synthase 2 (COX-2) | −1.37 |
| RELA/p65 | NF-κB subunit p65 | −1.10 |
| SITPEC | Evolutionarily conserved signalling intermediate in Toll pathway (ECSIT) | −1.33 |
| TOLLIP | Toll interacting protein | −1.27 |
| Trif dependent genes | ||
| PELI1 | E3 ubiquitin-protein ligase pellino homolog 1 | −1.08 |
| SARM1 | Sterile alpha and TIR motif-containing protein 1 | −1.23 |
| TBK1 | Serine/threonine-protein kinase TBK1 | −1.34 |
| TICAM2 | TIR domain-containing adapter molecule 2 (TRAM) | −1.32 |
| TRIF | TIR domain-containing adapter molecule 1 | −1.16 |
| Non pathway specific genes | ||
| CLECSF9 | C-type lectin domain family 4 member E | −1.24 |
| CSF3 | Granulocyte colony-stimulating factor (G-CSF) | −2.50 |
| CXCL10 | C-X-C motif chemokine 10 | −1.03 |
| HRAS | GTPase HRas (p21) | −1.17 |
| IFNG | Interferon-γ | −1.24 |
| IL2 | Interleukin 2 | −1.19 |
| IL10 | Interleukin 10 | −1.00 |
| LY86 | Lymphocyte antigen 86 | −1.13 |
| NR2C2 | Nuclear receptor subfamily 2 group C member 2 | −1.19 |
| PGLYRP1 | Peptidoglycan recognition protein 1 | −1.11 |
| PGLYRP2 | Peptidoglycan recognition protein 2 | −1.17 |
| PGLYRP3 | Peptidoglycan recognition protein 3 | −1.30 |
| PGLYRP4 | Peptidoglycan recognition protein 4 | −1.18 |
| PPARA | Peroxisome proliferator-activated receptor alpha | −1.17 |
| PRKRA | Interferon-inducible double stranded RNA-dependent protein kinase activator A | −1.29 |
| TLR1 | Toll like receptor 1 | −1.15 |
| TLR3 | Toll like receptor 3 | −1.29 |
| TLR5 | Toll like receptor 5 | −1.35 |
| TLR6 | Toll like receptor 6 | −1.23 |
| TLR8 | Toll like receptor 8 | −1.29 |
| TLR9 | Toll like receptor 9 | −1.07 |
| TLR10 | Toll like receptor 10 | −1.09 |
| UBE2N | Ubiquitin-conjugating enzyme E2 | −1.30 |
A value of −1 is equivalent to a 2 fold increase in gene expression in wildtype subjects compared to TLR4 polymorphic subjects. All fold changes presented were statistically significant with p value <0.05.